Table 2. Anti-TB activity of POE derivatives at 10 μg/mL concentration along with log P values .
| Compound |
Concentration
μg/mL/μM |
Inhibition (%) | Log p b |
| Controla | 0 | ||
| RIFA | 0.10 /0.12 | 88.70 | |
| RIFA | 1.0 /1.2 | 98.30 | |
| 3a | 10/ 43 | 3.60 | 1.14 |
| 3b | 10/ 39 | 21.70 | 0.89 |
| 3c | 10/ 44 | 45.42 | 1.01 |
| 3d | 10/ 37 | 27.93 | 2.19 |
| 3e | 10/ 35 | 33.50 | 0.94 |
| 3f | 10/ 41 | 3.42 | 0.58 |
| 3g | 10/ 41 | 9.83 | 1.85 |
| 3h | 10/ 37 | 19.89 | 1.06 |
| 3i | 10/ 34 | 41.06 | 3.05 |
| 3j | 10/ 31 | 45.70 | 2.41 |
| 3k | 10/ 29 | 22.44 | -0.48 |
| 3l | 10/ 43 | 56.00 | -1.72 |
| 3m | 10/62 | 51.23 | -0.18 |
| 3n | 10/55 | 31.70 | -0.55 |
a As negative control, bacteria were incubated at the same conditions without the presence of POE.
b The log P values (hydrophobic indicator) were calculated using the program CS ChemOffice Ultra ver. 11.0 (CambridgeSoft, Cambridge, MA, USA).