Table 4. Viability values of K562 cells treated with POE compounds at different concentrations and times along with IC50 values at 72 hours .
| Compound name | Concentration (µM) | Viability (% of Control) | IC50 (µM) at 72 h | ||
| 24 h | 48 h | 72 h | |||
| 3a | 0 | 100 | 100 | 100 | 100±10.0 |
| 25 | 82±4.5 | 77±4.0 | 70±2.0 | ||
| 50 | 70±5.0 | 68±0.5 | 62±2.5 | ||
| 100 | 65±5.5 | 62±4.5 | 58±2.5 | ||
| 125 | 55±3.0 | 50±4.0 | 47±3.0 | ||
| 150 | 42±5.0 | 40±4.5 | 36±2.0 | ||
| 3b | 0 | 100 | 100 | 100 | 100±4.0 |
| 25 | 85±2.5 | 75±4.2 | 67±4.0 | ||
| 50 | 72±4.0 | 65±1.5 | 60±3.0 | ||
| 100 | 68±3.5 | 60±2.5 | 55±3.5 | ||
| 125 | 60±3.5 | 50±5.5 | 45±4.0 | ||
| 150 | 55±4.0 | 42±4.0 | 32±3.0 | ||
| 3c | 0 | 100 | 100 | 100 | >150 |
| 25 | 98±2.0 | 95±1.0 | 93±2.5 | ||
| 50 | 95±2.5 | 94±2.0 | 91±3.0 | ||
| 100 | 92±2.0 | 91±3.0 | 88±1.0 | ||
| 125 | 86±2.0 | 80±5.0 | 75±2.5 | ||
| 150 | 80±5.0 | 74±4.0 | 67±3.0 | ||
| 3d | 0 | 100 | 100 | 100 | 100±2.0 |
| 25 | 93±2.0 | 85±0.5 | 68±2.5 | ||
| 50 | 80±0.5 | 62±1.5 | 57±3.5 | ||
| 100 | 75±3.5 | 55±2.5 | 50±4.0 | ||
| 125 | 63±4.0 | 50±3.0 | 45±2.0 | ||
| 150 | 52±5.0 | 40±4.5 | 35±3.0 | ||
| 3e | 0 | 100 | 100 | 100 | 25±8.0 |
| 25 | 75±4.0 | 55±4.0 | 45±3.5 | ||
| 50 | 62±2.0 | 40±3.5 | 30±3.0 | ||
| 100 | 45±3.0 | 27±3.5 | 15±2.5 | ||
| 125 | 30±4.0 | 20±2.0 | 12±3.0 | ||
| 150 | 22±4.0 | 17±3.5 | 8.0±2.0 | ||
| 3f | 0 | 100 | 100 | 100 | >100 |
| 25 | 93±3.0 | 90±1.0 | 88±3.5 | ||
| 50 | 90±2.0 | 87±3.0 | 86±3.0 | ||
| 100 | 88±3.0 | 85±1.0 | 82±2.0 | ||
| 125 | 80±5.0 | 75±2.0 | 68±3.0 | ||
| 150 | 72±5.0 | 66±4.0 | 62±4.0 | ||
| 3g | 0 | 100 | 100 | 100 | >100 |
| 25 | 92±2.4 | 89±1.2 | 88±2.0 | ||
| 50 | 90±1.6 | 85±3.3 | 84±2.2 | ||
| 100 | 87±3.2 | 83±1.3 | 82±2.4 | ||
| 125 | 82±3.0 | 80±3.0 | 70±5.0 | ||
| 150 | 75±5.0 | 70±4.5 | 66±4.0 | ||
| 3h | 0 | 100 | 100 | 100 | 100±3.0 |
| 25 | 83±3.5 | 75±4.2 | 67±4.0 | ||
| 50 | 73±2.5 | 65±4.5 | 58±5.0 | ||
| 100 | 67±5.5 | 50±1.5 | 47±2.5 | ||
| 125 | 60±2.0 | 50±3.5 | 40±2.0 | ||
| 150 | 55±5.0 | 45±2.0 | 33±4.0 | ||
| 3i | 0 | 100 | 100 | 100 | >100 |
| 25 | 95±3.5 | 92±1.5 | 90±1.5 | ||
| 50 | 93±2.5 | 88±3.5 | 87±2.5 | ||
| 100 | 90±2.0 | 87±3.0 | 85±1.0 | ||
| 125 | 82±4.0 | 83±2.0 | 80±2.0 | ||
| 150 | 78±2.0 | 75±1.5 | 70±1.0 | ||
| 3j | 0 | 100 | 100 | 100 | 25±5.0 |
| 25 | 70±3.0 | 52±3.0 | 45±3.0 | ||
| 50 | 60±2.5 | 43±3.0 | 32±2.0 | ||
| 100 | 42±3.5 | 25±1.5 | 20±2.0 | ||
| 125 | 33±2.0 | 20±3.0 | 16±2.0 | ||
| 150 | 25±3.0 | 15±1.5 | 10±1.0 | ||
| 3k | ND | ND | ND | ||
| 3l | ND | ND | ND | ||
| 3m | ND | ND | ND | ||
| 3n | 0 | 100 | 100 | 100 |
>100 |
| 25 | 97±1.0 | 95±1.0 | 91±1.5 | ||
| 50 | 95±2.5 | 92±4.0 | 90±1.0 | ||
| 100 | 93±1.0 | 90±2.0 | 88±2.0 | ||
| 125 | 90±1.0 | 84±1.0 | 80±1.5 | ||
| 150 | 85±2.0 | 77±3.5 | 70±5.0 | ||
| DOX | 0.5 | 50±2.0 | 40±4.0 | 25±5.0 | |
ND: not done.