FIG 4.

QTL mapping identifies four loci underlying TB susceptibility. (A, B) QTL scans of the numbers of lung CFU, the numbers of spleen CFU, and IFN-γ abundance in the lung identify four tuberculosis immunophenotype (Tip) loci on chromosomes 7, 15, and 16. The dashed lines in panel B represent a 5% false discovery rate for each trait based on permutation analysis. (C to E) The Tip loci on each chromosome are indicated at the marker with the peak LOD. (F to J) Allele effect plots for the indicated Tip loci. One hundred seventy F₂ mice (86 female and 84 male mice) were successfully genotyped and used for QTL mapping.