TABLE 1.
Tuberculosis immunophenotype (Tip) QTL in a (CC001 × CC042)F2 crossa
| QTL | Chromosome | Trait |
P
value |
Max LOD |
Peak marker | Peak (Mb) |
Bayes interval (Mb) |
Haplotype |
Inheritance mode |
Variance (%) |
|
|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | ||||||||||
| Tip1 | 7 | No. of spleen CFU |
<10−4 | 9.2 | gUNC13104259 | 72.1 | 3.6–72.9 | CAST | WSB | Additive | 17.6 |
| Tip2 | 7 | No. of spleen CFU |
<10−4 | 12.3 | gUNC13793270 | 125.4 | 124.7–127.3 | NZO | WSB | Recessive | 22.5 |
| Tip2 | 7 | IFN-γ level |
7 × 10−4 | 9.1 | gUNC13793270 | 125.4 | 121.0–130.7 | NZO | WSB | Recessive | 21.4 |
| Tip3 | 15 | IFN-γ level |
0.011 | 5.4 | mbackupUNC150396514 | 83.1 | 53.7–89.7 | CAST | 129 | Additive (nonlinear) |
13.5 |
| Tip4 | 16 | IFN-γ level |
0.046 | 4.2 | UNC26693650 | 40.8 | 4.5–44.7 | WSB | CAST | Additive (nonlinear) |
10.6 |
a
Low and high haplotypes are provided at the peak logarithm of the odds (LOD) of each QTL. High and low haplotypes are provided relative to each specific trait. P values were determined by the permutation test. The fraction of the variance explained by each QTL was estimated by fitting a single QTL model for each trait at the respective peak locations with sex and batch as covariates. NZO, New Zealand Obese.