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. 2019 Jun 2;244(12):972–982. doi: 10.1177/1535370219854678

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Figure 5. — Downregulation of WWOX confers tamoxifen-resistance by inactivating Hippo signaling pathway. (a) Immunoblot analyses of WWOX and YAP expression following siRNA-mediated WWOX and YAP knockdown in MCF7 cells. (b) The survival rates of siCon, siYAP-1, siYAP-2, siWWOX, siWWOX/YAP-1, and siWWOX/YAP-2 cells after treatment with 4-OHT for 2, 4, or 6 days. (c) siCon, siYAP-1, siYAP-2, siWWOX-1, siWWOX-1/YAP-1, and siWWOX-1/YAP-2 cells were treated with 4-OHT (5 μΜ) for 4 days and examined by FACS. (A color version of this figure is available in the online journal.)