Table 3:

Statistical analysis of key nonmotor features in those with and without ATP1A3 mutations. Where there is missing data due to patient-specific issues, information is given in Supplementary Data Table 2. Numeric values are counts (column percentages) and means (SD). SCID = Structured Clinical Interview for DSM-IV, Y-BOCS = Yale Brown Obsessive Compulsive Symptom Scale. Of the psychiatric symptom scales, all except the SCID yield raw scores with higher values representing greater current symptom burden. The SCID yields lifetime diagnoses of psychiatric illness.

Characteristics		Carriers N=44	Noncarriers N=44	p-Value
Cognitive Function	Trailmaking B	35.8 (10.3)	51.2 (12.0)	< 0.001
	Linguistic Fluency	33.9 (8.5)	46.9 (9.2)	< 0.001
	Semantic Fluency	37.1 (13.1)	51.4 (9.6)	< 0.001
Psychiatric symptoms	SCID Mood Disorder	16 (50%)	7 (22%)	0.036
	SCID Anxiety Disorder	13 (42%)	12 (38%)	0.080
	SCID Psychosis	7 (22%)	0 (0%)	0.011
	SCID Substance Abuse	11 (34%)	8 (26%)	0.590
	Hamilton Anxiety	7.2 (7.3)	5.2 (8.7)	0.240
	Hamilton Depression	10.5 (9.2)	6.3 (7.7)	0.051
	YBOCS	3.2 (6.3)	0.9 (3.1)	0.385