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NAD+ MRS in human brain. Left, Chemical structure of NAD+ showing the H2, H4 and H6 protons present on the nicotinamide moiety which are the target of downfield spectroscopy. Inset, Sagittal section from the anatomical images of the brain showing the position of MR voxel. Right, MR spectra acquired from the healthy human brain showing the three peaks arising from NAD+ at 8.9, 9.1 and 9.35 ppm
