. Author manuscript; available in PMC: 2021 Dec 1.

Published in final edited form as: J Muscle Res Cell Motil. 2019 May 27;41(4):313–327. doi: 10.1007/s10974-019-09517-x

Table 1.

Major stages of mouse heart development and key transcription factors implicated in cardiac development in mice.

Stage in the heart development	Embryonic day	Transcription factors
Cardiac crescent	E7.5	Nkx2–5, Mesp1, Mesp2
Linear heart tube	E8.0	GATA4, MEF2C, Mesp1, Mesp2, Hand1, Hand2
Cardiac looping	E8.5-E9.5	Nkx2–5, Tbx5, GATA4, MEF2C, Hand1, Hand2
Chamber formation	E10-E12	Nkx2–5, Tbx5, Hand1, Hand2, GATA4
Maturation/septation	E12-birth	Nkx2–5, Tbx5, GATA4

Abbreviations: Nkx2–5 - NK2 homeobox 5 transcription factor, Mesp1/Mesp2 - mesoderm posterior bHLH (basic helix-loop-helix) transcription factor 1/2, GATA4 - zinc finger protein 4 that bind the consensus DNA sequence (T/A)GATA(A/G), MEF2C - myocyte enhancer binding factor 2C, Hand1/Hand2 - heart- and neural crest derivatives-expressed protein 1/2, Tbx5- T-box transcription factor 5. E denotes embryonic day.