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. 2019 Oct 14;51(11):578–585. doi: 10.1152/physiolgenomics.00054.2019

Fig. 1.

Fig. 1.

Blood pressure. SHR-A3 and SHR-A3(IgH-B2) rats were maintained for 8 wk on a stroke-inducing diet (1% NaCl in drinking water) starting at 20 wk of age. Systolic blood pressure (BP) was measured by telemetry immediately before and weekly during 8 wk of salt loading in SHR-A3 and SHR-A3(IgH-B2) congenic rats. BP was elevated during salt loading in both lines, and no significant difference was observed either before or during salt loading. Note, however, that progressive loss of SHR-A3 occurred during salt loading as a result of stroke or clinical phenotypes that reached our euthanasia threshold. In SHR-A3 animals, systolic BPs approaching 230 mmHg were predictive of imminent stroke or clinical pathology related to cerebrovascular disease. SHR-A3 n = 9, SHR-A3(IgH-B2), n = 7.