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. 2019 Sep 26;127(5):1349–1359. doi: 10.1152/japplphysiol.00469.2019

Fig. 4.

Fig. 4.

Exercise training attenuates heart failure-induced downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and NAD(P)H quinone dehydrogenase 1 (NQO-1) in the rostral ventrolateral medulla (RVLM). A: Nrf2 mRNA [Sham sedentary (Sham-Sed), n = 6; sham exercise-trained (Sham-ExT), n = 6; chronic heart failure sedentary (CHF-Sed), n = 5; CHF-ExT n = 6)] and Nrf2 protein (Sham-Sed, n = 6; Sham-ExT, n = 5; CHF-Sed, n = 6; CHF-ExT, n = 4) in the RVLM. B: NQO-1 mRNA and protein expression in the RVLM. C: Nrf2 mRNA and protein expression in the visual cerebral cortex. D: correlation between Nrf2 mRNA in the RVLM with ejection fraction (EF). E: correlation between Nrf2 protein expression in the RVLM with EF. F: Nrf2 antibody validation by immunoblot after preabsorption with a blocking peptide. n = no. of mice.