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A schematic of the nuclear factor erythroid 2-related factor 2 (Nrf2)/Keap1 signaling pathway and some of the potential mechanisms by which exercise training (ExT) impacts Nrf2, antioxidant enzymes, oxidative stress, and sympathetic nerve activity. ARE, antioxidant response element; NQO-1, NAD(P)H quinone dehydrogenase 1; ROS, reactive oxygen species; RVLM, rostral ventrolateral medulla.
