Fig. 2.

Selected features to highlight the tricarboxylic acid (TCA) cycle; alanine, aspartate, and glutamate metabolism; and other key metabolites. A: metabolites from intrauterine growth restriction (IUGR; n = 10 fetuses) and control (CON; n = 8 fetuses) fetal skeletal muscle. B: features from IUGR (shaded box) and CON (open box) fetal arterial (IUGR-A, CON-A) and venous (IUGR-V, CON-V) plasma samples. Data are from MetaboAnalyst as presented in Figs. 1 and 3 and analyzed using Student’s t test (A) or two-way ANOVA (B). *False discovery rate-adjusted P ≤ 0.1 by Tukey’s post hoc test. Box denotes 25th and 75th percentiles; bars denote minimum and maximum values. A, arterial; V, venous.