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. 2019 Sep 4;317(5):R615–R629. doi: 10.1152/ajpregu.00115.2019

Fig. 3.

Fig. 3.

Metabolomic profiles of arterial and venous plasma of intrauterine growth restriction (IUGR) and control (CON) fetuses. A: partial least squares-discriminant analysis was used to identify metabolites with changes in abundance that defined separation of samples between the IUGR (n = 10 fetuses) and CON (n = 8 fetuses) groups. B: heat map of the 30 metabolites with the highest variable importance in projection scores. For simplicity, each square is representative of the mean levels of that metabolite per group and vessel. Row values are normalized for each metabolite, and quantitative changes are color coded from red (high) to blue (low). A, arterial plasma; FBP, fructose 1,6-bisphosphate; G3P, sn-glycerol 3-phosphate; NAML, N-Acyl-d-mannosaminolactone; THcHDO, 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione; V, venous plasma. ANOVA was performed on all 4 groups (CON-A, CON-V, IUGR-A, and IUGR-V). Student’s t test was performed separately on the arterial and venous plasma of IUGR versus CON. *False discovery rate-adjusted P ≤ 0.05.