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Potential mechanisms responsible for exercise-induced cytoprotection against doxorubicin cellular toxicity include increased endogenous antioxidant enzyme expression, increased heat shock protein 72 (HSP72) expression, and/or increased multidrug resistance protein (MRP) expression. GPX, glutathione peroxidase; SOD, superoxide dismutase; ABCB, ATP-binding cassette transporter subfamily B.
