Plasma apolipoproteins A1 (ApoA1) and ApoA2 levels in peroxisome proliferator-activated receptor-α (PPARα) wild-type (Pparafl/fl) and PPARα hepatocyte-specific knockout (PparaHepKO) mice fed a high-fat diet (HFD). Plasma ApoA1 (A) and Apo-A2 (B) as measured by NMR spectroscopy. ApoA1 (C) and ApoA2 (D) distribution profiles for very-low-density lipoprotein (VLDL), intermediate-density lipoproteins (IDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Values are means ± SE; *P < 0.05 vs. normal fed diet (NFD) Pparafl/fl; ^P < 0.05 vs. NFD PparaHepKO; n = 6 and12, Pparafl/fl NFD, HFD; n = 6 and 8, PparaHepKO NFD, HFD. n, number of mice. All circles, NFD; all squares, HFD.