Table 1.

Body and organ weights in Ppara^fl/fl and Ppara^HepKO mice

Parameter	Pparafl/fl NFD	Pparafl/fl HFD	PparaHepKO NFD	PparaHepKO HFD	Diet P value	Genotype P value	Interaction P value
n	16	13	6	8
BW, g	34.9 ± 1.4	55.2 ± 1.5	37.1 ± 1.5	51.1 ± 1.1	0.0115*	0.3629	0.6625
BL, cm	9.9 ± 0.09	10.5 ± 0.08	9.9 ± 0.13	10.5 ± 0.04	<0.0001*	0.3389	0.6402
HW, mg	159.3 ± 5.2	172.2 ± 10.8	176.2 ± 9.5	171.6 ± 4.3	0.4659	0.1258	0.6675
HW:BW, mg/g	4.6 ± 0.19	3.1 ± 0.15	4.7 ± 0.37	3.3 ± 0.08	<0.0001*	0.3215	0.8271
HW:BL, mg/cm	16.1 ± 0.55	16.5 ± 1	17.7 ± 1.1	16.2 ± 0.4	0.5029	0.4054	0.2561
LW, mg	1.3 ± 0.4	2.5 ± 0.25	1.3 ± 0.12	3 ± 0.4	<0.0001*	0.2465	0.2833
LW/BW, mg/g	0.038 ± 0.001	0.044 ± 0.003	0.035 ± 0.002	0.058 ± 0.002	0.0005*	0.1249	0.0353*
LW/BL, mg/cm	0.13 ± 0.004	0.23 ± 0.04	0.13 ± 0.01	0.28 ± 0.03	<0.0001*	0.1045	0.1139
Epidydmal FW, g	0.91 ± 0.13	1.8 ± 0.13	1.2 ± 0.2	1.57 ± 0.13	0.0167*	0.4358	0.6399
Visceral FW g	0.75 ± 0.1	2.9 ± 0.08	0.87 ± 0.16	2.8 ± 0.14	<0.0001*	0.3189	0.5906
Total fat, g	1.66 ± 0.24	4.77 ± 0.17	2.03 ± 0.37	4.37 ± 0.21	<0.0001*	0.3345	0.9053

Values are means ± SE: n = no. of mice. Ppara^fl/fl, peroxisome proliferator-activated receptor-α (PPARα) wild-type mice; Ppara^HepKO, knockout mice; NFD, normal fat diet; HFD, high-fat diet; BW, body weight; BL, body length; HW, heart weight; LW, liver weight; FW, fat weight.

^*P < 0.05.