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. 2019 Jul 19;317(5):E879–E898. doi: 10.1152/ajpendo.00065.2019

Fig. 6.

Fig. 6.

Correlation plot for regulatory components with respect to metabolites in entire cohort (A), controls (B), subjects with posttraumatic stress disorder (PTSD; C), and fold change in correlations with respect to correlations in controls (the fold changes >4 are capped at 4; D). Correlations are shown for the statistically significant correlations (P < 0.05; Supplemental Table S6). It is observed that across the correlation plots A–C, significant correlations are conserved for the cross-correlations between homeostatic model assessment of insulin resistance (HOMAIR), γ-glutamyltransferase (GGT), high-sensitivity C-reactive protein (hs-CRP), hypoxanthine and glycolytic metabolites, amino acid metabolites, and triglyceride metabolites. On the fold change plot, it is noted around 2- to 4-fold higher correlations in subjects with PTSD between GGT, hs-CRP, hypoxanthine, and HOMAIR, indicating stronger association between oxidative stress, inflammation, and insulin resistance, along with similar level of increase in correlation between regulatory components and metabolites except for fatty acids. There is a notable increase in association between cortisol suppression and citrate, alanine, tyrosine, HOMAIR, and GGT. Dex, dexamethasone; Urn., urinary.