Table 2.
Transgenic expression of CAIII in mouse heart does not alter baseline functions
| WT | CAIII | |
|---|---|---|
| n | 4 | 3 |
| Heart rate, beats/min | 480 | 480 |
| LVPmax, mmHg | 69.7 ± 2.3 | 71.4 ± 1 |
| LVPmin, mmHg | 4.8 ± 0.8 | 4.6 ± 0.2 |
| APmax, mmHg | 60.4 ± 0.2 | 61.4 ± 0.4 |
| APmin, mmHg | 47.8 ± 0.3 | 46.6 ± 0.4 |
| SV, μL/mg | 0.164 ± 0.015 | 0.195 ± 0.010 |
| +dP/dt, mmHg/s | 3,749.8 ± 129.4 | 3,931.4 ± 93.3 |
| −dP/dt, mmHg/s | −2,697.0 ± 93.84 | −2,776.3 ± 115.6 |
Values are means ± SE; n = no. of mice. Ex vivo working-heart functions of 3-mo-old transgenic mice tested under baseline conditions at 10-mmHg preload, 55-mmHg afterload, and heart rate of 480 beats/min showed no difference from wild-type (WT) control. APmax and APmin, maximum and minimum aortic pressure, respectively; LVPmax and LVPmin, maximum and minimum left ventricular pressure, respectively; SV, left ventricular stroke volume. Statistical analysis was performed using Student’s t test.