Table 2.
Most significantly affected proteins in diabetic and idiopathic gastroparesis
| Proteins | Fold Change | Adjusted P Value |
|---|---|---|
| Diabetic gastroparesis vs. controls (n = 9 and 5) | ||
| Trefoil factor 2 | −11.3 | 1.1 × 10−10 |
| FABP3, heart | −2.8 | 1.9 × 10−5 |
| GPD1 | −12.2 | 7.8 × 10−5 |
| PRSS1 | −2.3 | 1.8 × 10−4 |
| IL-1R2 | −1.5 | 1.7 × 10−3 |
| CSF3 | −1.3 | 2.4 × 10−3 |
| CA3 | −8.3 | 2.8 × 10−3 |
| AHSG | −1.2 | 6.1 × 10−3 |
| CA1 | −4.7 | 6.7 × 10−3 |
| CAMK2B | 1.7 | 7.2 × 10−3 |
| Idiopathic gastroparesis vs. controls (n = 7 and 5) | ||
| TFF2 | −11.3 | 2.7 × 10−10 |
| SLIRK5 | 2.0 | 2.6 × 10−4 |
| PGD | 1.5 | 3.3 × 10−4 |
| FABP3, heart | −2.4 | 3.7 × 10−4 |
| GPD1 | −9.2 | 4.4 × 10−4 |
| NRG1 | 1.2 | 4.4 × 10−4 |
| FGF12 | 1.3 | 5.7 × 10−4 |
| CSF3 | −1.4 | 6.4 × 10−4 |
| AIP | 1.5 | 6.9 × 10−4 |
| FGF1 | 1.9 | 6.9 × 10−4 |
AHSG, α-2-HS-glycoprotein; AIP, AH receptor-interacting protein; CA1, carbonic anhydrase 1; CA3, carbonic anhydrase 3; CAMK2B, calcium/calmodulin-dependent protein kinase type II subunit-β; CSF3, granulocyte colony-stimulating factor; FABP3, fatty acid-binding protein; FGF1 and -12, fibroblast growth factor 1 and 12, respectively; GPD1, glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; IL-1R2, interleukin-1 receptor type 2; NRG1, neuregulin-1; PGD, 6-phosphogluconate dehydrogenase, decarboxylating; PRSS1, trypsin-1; SLIRK5, SLIT and NTRK-like protein 5; TFF2, trefoil factor 2.