Table 3.
Summary of ingenuity pathway analysis in diabetic and idiopathic gastroparesis
| Ingenuity Canonical Pathways | Adjusted P Value | Molecules |
|---|---|---|
| Diabetic castroparesis vs. controls | ||
| Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis | 7.94E-09 | CAMK2B, PRSS1, IL17RA, MMP3, SFRP1, CAMK2D, IL1R2, FRZB, CAMK2A, IL6ST, and IL17RC |
| ERK5 signaling | 8.91E-05 | YWHAE, YWHAZ, IL6ST, and BAD |
| Myc-mediated apoptosis signaling | 0.000115 | FASLG, YWHAE, YWHAZ, and BAD |
| Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis | 0.00012 | BGLAP, MMP3, SFRP1, IL1R2, FRZB and BAD |
| Cross-talk between dendritic cells and natural killer cells | 0.000214 | CAMK2B, FASLG, CAMK2D and CAMK2A |
| Acute-phase response signaling | 0.000288 | APCS, C3, HMOX2, AHSG and IL6ST |
| IGF-1 signaling | 0.000501 | IGFBP2, YWHAE, YWHAZ and BAD |
| iCOS-iCOSL signaling in T helper cells | 0.000741 | CAMK2B, CAMK2D, CAMK2A and BAD |
| Role of IL-17A in psoriasis | 0.000813 | IL17RA and IL17RC |
| PI3K signaling in B lymphocytes | 0.001072 | CAMK2B, C3, CAMK2D and CAMK2A |
| Idiopathic gastroparesis vs. controls | ||
| Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | 6.31E-12 | CAMK2B, CSF2, SRC, CAMK2D, IL1R2, AKT2, MAPKAPK2, IL6ST, CAMK2A, PRSS1, IL17RA, IL1R1, IL1RAPL2, PRSS2, PDIA3, MIF, and IL17RC |
| Role of cytokines in mediating communication between immune cells | 7.41E-07 | IL2, CSF2, IL24, IL20, CSF3, and IFNB1 |
| Crosstalk between dendritic cells and natural killer cells | 9.33E-07 | CAMK2B, IL2, CSF2, CD209, CAMK2D, IFNB1, and CAMK2A |
| PPARα/RXRα activation | 1.55E-06 | TGFB3, AIP, IL1R1, IL1RAPL2, TGFB2, INSR, GPD1, PDIA3, and IL1R2 |
| Aryl hydrocarbon receptor signaling | 1.95E-06 | TGFB3, GSTA3, SRC, AIP, TFF1, TGFB2, MDM2, and GSTP1 |
| p38 MAPK signaling | 6.61E-06 | TGFB3, MAPKAPK3, IL1R1, IL1RAPL2, TGFB2, IL1R2, and MAPKAPK2 |
| LPS/IL-1-mediated inhibition of RXR function A | 6.92E-06 | CHST2, GSTA3, FABP3, IL1R1, IL1RAPL2, HS6ST1, IL1R2, GSTP1, and CHST15 |
| Apelin cardiac fibroblast signaling pathway | 7.59E-06 | TGFB3, ANGPT2, TGFB2, and AKT2 |
| Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis | 9.77E-06 | BGLAP, SRC, CSF2, IL1R1, ADAMTS5, GSN, IL1RAPL2, IL1R2, and AKT2 |
| Xenobiotic metabolism signaling | 1.02E-05 | CAMK2B, CHST2, GSTA3, AIP, CAMK2D, HS6ST1, GSTP1, ESD, CAMK2A, and CHST15 |
AIP, AH-interacting protein; ADAMTS5, a disintegrin and metalloproteinase with thrombospondin-like motifs; BGLAP, bone γ-carboxyglutamate protein; CAMK2A, -B, and -D; CHST, calcium/calmodulin-dependent protein kinase type II subunit 2α, β, and -δ, respectively; CSF1, -2, and 3, colony stimulating factor 1, 2, and 3; FRZB, and frizzled related protein; GSN, gelsolin; GSTA, glutathione-S-transferase-α; GTSP, glutathione-S-transferase P; ILR1, interleukin 1 receptor type I; IL1RAPL2, X-linked interleukin-1 receptor accessory protein-like 2; INSR, insulin receptor; MAPKAPK3, mitogen-activated protein kinase-activated protein kinase 2; PI3K, phosphatidylinositol 3-kinase; PRSS1, serine protease 1; RXR, retinoid X receptor; TFF1, trefoil factor 2; TGFB3, transforming growth factor-β.