Table 1.
Reporter Line | Dox Admin | Age When Examined | TI Cell Squamous (Pdpn+, Sftpc−) | TII Cell Cuboidal (Pdpn−, Sftpc+) |
---|---|---|---|---|
R22/tet-O-Cre/tdT | E10–18 | PN 4 wk | ++++ | −/+ |
E12–15 | PN 4 wk | + | ND | |
E15–18 | E18 | +++++ | ND | |
E15–18 | PN7 | ++++ | ND | |
E15–18 | PN 4 wk | ++++ | −/+ | |
114/tet-O-Cre/tdT | E10–18 | PN 4 wk | ++ | ++++ |
E12–15 | PN 4 wk | + | + | |
E15–18 | E18 | + | +++++ | |
E15–18 | PN7 | ++ | ++++ | |
E15–18 | PN 4 wk | ++ | ++++ |
The results of morphologic analyses shown in Figs. 1 and 2 and described in the text are summarized in this table. The amount and pattern of TdTomato cell staining were evaluated qualitatively by inspecting multiple images for each of the time windows of Dox administration in the 114 and R22 lines. “n” is described for each time point in the Figure legends. Note that the patterns fall largely into two groups, with R22 leading to virtually all TI cells and 114 to “mostly” TII cells. Dox, doxycycline; ND, not detected; PN, postnatal: +/−, rare; +, very few/few; ++, patchy; ++++, most; +++++, extensive.