Table 2.
Differentially expressed canonical pathways between PN 4 wk TI and PN 4 wk TII cells
| PN 4 wk TI Cells |
PN 4 wk TII Cells |
||
|---|---|---|---|
| Canonical Pathway | −log(P Value) | Canonical Pathway | −log(P Value) |
| Hepatic fibrosis/hepatic stellate cell activation | 23.1 | Superpathway of cholesterol biosynthesis | 11.7 |
| Axonal guidance signaling | 21.1 | Cholesterol biosynthesis I | 9.43 |
| Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | 17.9 | Cholesterol biosynthesis II (via 24,25- dihydrolanosterol) | 9.43 |
| Leukocyte extravasation signaling | 16 | Cholesterol biosynthesis III (via desmosterol) | 9.43 |
| Phagosome formation | 14 | Fatty acid β-oxidation I | 5.44 |
| Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis | 13.8 | Zymosterol biosynthesis | 5.14 |
| NF-κB signaling | 13 | Stearate biosynthesis I (animals) | 4.29 |
| Colorectal cancer metastasis signaling | 12.5 | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | 4.23 |
| Molecular mechanisms of cancer | 12.4 | TR/RXR activation | 4.16 |
| Integrin signaling | 12.2 | Ephrin A signaling | 3.91 |
| Granulocyte adhesion and diapedesis | 12 | Glutaryl-CoA degradation | 3.61 |
| PI3K signaling in B lymphocytes | 11.7 | LXR/RXR activation | 3.43 |
| B cell receptor signaling | 11.5 | Glutathione-mediated detoxification | 3.14 |
| Fcγ receptor-mediated phagocytosis in macrophages and monocytes | 10.9 | Mevalonate pathway I | 2.98 |
| Dendritic cell maturation | 10.8 | Arginine degradation I (arginase pathway) | 2.96 |
| Virus entry via endocytic pathways | 10.4 | GDP-glucose biosynthesis | 2.73 |
| IL-8 signaling | 10.3 | p53 signaling | 2.58 |
| Glioblastoma multiforme signaling | 10.3 | Lysine degradation II | 2.58 |
| Thrombin signaling | 10.3 | Triacylglycerol biosynthesis | 2.55 |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 10.2 | Glucose and glucose-1-phosphate degradation | 2.54 |
| PPARα/RXRα activation | 9.62 | Paxillin signaling | 2.5 |
| Phospholipase C signaling | 9.53 | Tryptophan degradation III (eukaryotic) | 2.4 |
| Osteoarthritis pathway | 9.29 | Epoxysqualene biosynthesis | 2.36 |
| Gαq signaling | 9.08 | Spermine biosynthesis | 2.36 |
| TREM1 signaling | 9.06 | Proline degradation | 2.36 |
Differentially expressed (PN 4 wk TI vs. PN 4 wk TII cells) canonical pathways, as analyzed by ingenuity pathways (see materials and methods). PN, postnatal.