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. 2019 Aug 21;317(5):L653–L666. doi: 10.1152/ajplung.00503.2018

Table 2.

Differentially expressed canonical pathways between PN 4 wk TI and PN 4 wk TII cells

PN 4 wk TI Cells
PN 4 wk TII Cells
Canonical Pathway −log(P Value) Canonical Pathway −log(P Value)
Hepatic fibrosis/hepatic stellate cell activation 23.1 Superpathway of cholesterol biosynthesis 11.7
Axonal guidance signaling 21.1 Cholesterol biosynthesis I 9.43
Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis 17.9 Cholesterol biosynthesis II (via 24,25- dihydrolanosterol) 9.43
Leukocyte extravasation signaling 16 Cholesterol biosynthesis III (via desmosterol) 9.43
Phagosome formation 14 Fatty acid β-oxidation I 5.44
Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis 13.8 Zymosterol biosynthesis 5.14
NF-κB signaling 13 Stearate biosynthesis I (animals) 4.29
Colorectal cancer metastasis signaling 12.5 Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 4.23
Molecular mechanisms of cancer 12.4 TR/RXR activation 4.16
Integrin signaling 12.2 Ephrin A signaling 3.91
Granulocyte adhesion and diapedesis 12 Glutaryl-CoA degradation 3.61
PI3K signaling in B lymphocytes 11.7 LXR/RXR activation 3.43
B cell receptor signaling 11.5 Glutathione-mediated detoxification 3.14
Fcγ receptor-mediated phagocytosis in macrophages and monocytes 10.9 Mevalonate pathway I 2.98
Dendritic cell maturation 10.8 Arginine degradation I (arginase pathway) 2.96
Virus entry via endocytic pathways 10.4 GDP-glucose biosynthesis 2.73
IL-8 signaling 10.3 p53 signaling 2.58
Glioblastoma multiforme signaling 10.3 Lysine degradation II 2.58
Thrombin signaling 10.3 Triacylglycerol biosynthesis 2.55
Role of pattern recognition receptors in recognition of bacteria and viruses 10.2 Glucose and glucose-1-phosphate degradation 2.54
PPARα/RXRα activation 9.62 Paxillin signaling 2.5
Phospholipase C signaling 9.53 Tryptophan degradation III (eukaryotic) 2.4
Osteoarthritis pathway 9.29 Epoxysqualene biosynthesis 2.36
Gαq signaling 9.08 Spermine biosynthesis 2.36
TREM1 signaling 9.06 Proline degradation 2.36

Differentially expressed (PN 4 wk TI vs. PN 4 wk TII cells) canonical pathways, as analyzed by ingenuity pathways (see materials and methods). PN, postnatal.