Table 3.
Differentially expressed canonical pathways between E18 pre-TI cells and PN 4 wk TII cells
| Canonical Pathway | −log(P Value) |
|---|---|
| Hepatic fibrosis/hepatic stellate cell activation | 16.5 |
| Axonal guidance signaling | 16.3 |
| Molecular mechanisms of cancer | 10.4 |
| Leukocyte extravasation signaling | 9.99 |
| Phagosome formation | 9.29 |
| Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | 9.02 |
| NF-κB signaling | 8.92 |
| B cell receptor signaling | 8.12 |
| Integrin signaling | 7.55 |
| Role of tissue factor in cancer | 7.12 |
| Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis | 6.95 |
| Glioblastoma multiforme signaling | 6.6 |
| Actin cytoskeleton signaling | 6.59 |
| PTEN signaling | 6.5 |
| PI3K signaling in B lymphocytes | 6.44 |
| ILK signaling | 6.38 |
| NF-κB activation by viruses | 6.21 |
| Virus entry via endocytic pathways | 6.18 |
| PPARα/RXRα activation | 5.91 |
| Dendritic cell maturation | 5.86 |
| Thrombin signaling | 5.83 |
| Osteoarthritis pathway | 5.81 |
| Wnt/Ca+ pathway | 5.74 |
| Colorectal cancer metastasis signaling | 5.65 |
| Sphingosine-1-phosphate signaling | 5.49 |
When E18 pre-TI cells are compared with PN 4 wk TII cells by ingenuity pathway analysis, canonical pathways DE in pre-TI cells are very similar (pathways in common are shown in bold) to the DE canonical pathways in adult TI cells shown in Table 2. DE, differential expression; PN, postnatal.