Table 4.
Differentially expressed canonical pathways between E18 pre-TII cells and PN 4 wk TI cells
| Canonical Pathway | −log(P Value) |
|---|---|
| Ephrin A signaling | 7.27 |
| Growth hormone signaling | 5.96 |
| EIF2 signaling | 5.79 |
| AMPK signaling | 4.34 |
| Fc Epsilon RI signaling | 4.25 |
| TR/RXR activation | 4.19 |
| IGF-1 signaling | 4.14 |
| Mouse embryonic stem cell pluripotency | 4.14 |
| Axonal guidance signaling | 3.9 |
| Insulin receptor signaling | 3.87 |
| p53 signaling | 3.83 |
| EGF signaling | 3.83 |
| Melanocyte development and pigmentation signaling | 3.78 |
| JAK/Stat signaling | 3.75 |
| ErbB signaling | 3.72 |
| Paxillin signaling | 3.71 |
| mTOR signaling | 3.71 |
| CNTF signaling | 3.69 |
| UVA-induced MAPK signaling | 3.68 |
| Breast cancer regulation by Stathmin1 | 3.63 |
| Regulation of the epithelial-mesenchymal transition pathway | 3.52 |
| Superpathway of cholesterol biosynthesis | 3.45 |
| ERK/MAPK signaling | 3.45 |
| NGF signaling | 3.33 |
| PDGF signaling | 3.29 |
When embryonic day E18 pre-TII cells are compared with postnatal (PN) 4 wk TI cells by ingenuity pathway analysis, the canonical pathways differentially expressed in pre-TII cells have fewer similarities (shown in bold) to those in adult TII cells than the comparison between E18 pre-TI and 4 wk TII cells shown in Table 3. TI, TII, alveolar type I and II cells; CNTF, ciliary neurotrophic factor; EIF, eukaryotic translation initiation factor; mTOR, mechanistic target of rapamycin; NGF, nerve growth factor..