Fig. 9.

Schematic describing our proposed pathway of interaction between TRPV4 and mitochondrial fragmentation in SuHx-MVECs (solid lines) as well as other established pathways linking mitochondrial dysfunction to EC migration/proliferation (dashed lines). ^aIncreased ROS production, decreased basal/maximal respiration, increased fission, and evidence of glycolytic shift. ^bDirect effects of mtROS on transcription (3). ^cChanges in fuel utilization following glycolytic shift providing carbons (i.e., anaplerosis) for generation of metabolites essential for biosynthetic activities such as proliferation (79).