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. 2019 Aug 28;317(5):L667–L677. doi: 10.1152/ajplung.00175.2019

Fig. 1.

Fig. 1.

Post-cecal ligation and puncture (CLP) mice demonstrate suppressed inflammatory response to intratracheal (IT) lipopolysaccharide (LPS). A: we performed CLP or sham surgery on day 0. Three days after surgery, we challenged animals with IT LPS (3 μg/g body wt). Animals were harvested 2 days after IT LPS. B: post-CLP animals had decreased number of leukocytes per milliliter in bronchoalveolar lavage (BAL) fluid 2 days after IT LPS. C: post-CLP animals demonstrated less alveolar injury 2 days after IT LPS, based on protein concentrations in BAL fluid. D: lung histological section from a sham animal (stained with H&E) showed evidence of lung inflammation 2 days after IT LPS. E: lung histological section from a CLP animal (stained with H&E) 2 days after IT LPS showed minimal evidence of lung inflammation. Scale bars on lower-magnification images = 500 μm and those on higher-magnification images = 100 μm. *P < 0.05 by Student’s t test; n = 5 each group.