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. 2019 Aug 7;317(5):L569–L577. doi: 10.1152/ajplung.00080.2018

Fig. 5.

Fig. 5.

Effects of scavengers of mitochondrial (mitoTEMPO) or extra-mitochondrial (TEMPO) superoxide on the hypoxia-elicited decreases in the levels of SM22α and calponin. Representative Western blot bands and quantitative analysis of cartilage oligomeric matrix protein (COMP) level under 1% and 3% O2 (*P < 0.05, one-way ANOVA with Newman-Keuls correction, n = 5) (A) and calponin (n = 8) and SM22α (n = 9) under 1% O2 (*P < 0.05, **P < 0.01, one-way ANOVA with Newman Keuls correction) (B). CTL, normoxia; H48, hypoxia for 48 h; T, 0.5 μM TEMPO under normoxia; H48 + T, 1% O2 for 48 h in the presence of 0.5 μM TEMPO; MT, 0.5 μM mitoTEMPO under normoxia; H48 + MT, 1% O2 for 48 h in the presence of 0.5 μM mitoTEMPO.