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. 2019 Oct 11;317(5):H1166–H1172. doi: 10.1152/ajpheart.00464.2019

Fig. 1.

Fig. 1.

Insulin-induced vasoconstriction in obesity and the role of endothelin-1 (ET-1) signaling. A: peak lower-limb vascular resistance (VR) during a 2-h oral glucose tolerance test (OGTT; 75 g glucose load) in lean (n = 8) and obese (n = 8) subjects. Plasma glucose and insulin, mean arterial pressure (MAP), and femoral artery blood flow at baseline and at peak VR are also presented; individual responses are displayed. B: ET-1 receptor inhibitor (bosentan, 10 µM) attenuates insulin-induced vasoconstriction in isolated omental adipose tissue resistance arteries from obese subjects (n = 6; individual responses presented). AUR, area under curve. *P < 0.05, difference between groups; #P = 0.09, trend for effect of time point; †P < 0.05, effect of time point; ‡P < 0.05, effect of ET-1 receptor inhibition. Data are expressed as means ± SE.