Fig. 4.

Effect of the Rho kinase inhibitor Y-27632 on the voltage-dependent L-type Ca²⁺ channel agonist Bay K8644-induced afferent arteriole vasoconstriction. A: afferent arteriolar responses to increasing concentrations of Bay K8644 in the absence and presence of the Rho kinase inhibitor Y-27632 at 5 µM. Data represent the actual diameters from each group. B: same data normalized as a percentage of the control diameter for each group. Values are expressed as means ± SE; n, number of kidneys. *P < 0.05 vs. baseline diameter in the same group; †P < 0.05 vs. vasoconstriction with Bay K8644 alone at the same concentration.