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. 2019 Aug 21;317(5):F1132–F1141. doi: 10.1152/ajprenal.00212.2018

Fig. 6.

Fig. 6.

Effect of the Rho kinase inhibitors Y-27632 and RKI-1447 on KCl-induced elevation of intracellular Ca2+ concentration ([Ca2+]i) in cultured rat aortic A7r5 smooth muscle cells. Changes in [Ca2+]i were estimated by fura-2 fluorescence [ratio of fluorescence at 340 nm to that at 380 nm (F340-to-F380 ratio)] during KCl-induced depolarization of cultured rat aortic A7r5 smooth muscle cells. A: effect of Y-27632 on KCl-induced elevation of [Ca2+]i. B: effect of RKI-1447 on KCl-induced elevation of [Ca2+]i. C: representative [Ca2+]i traces of 90 mM KCl alone and with 10 µM Y-27632 in cultured rat aortic A7r5 smooth muscle cells. Each bar (A and B) represents the mean ± SE. The number above each bar indicates the number of cells studied in each group. *P < 0.05 vs. the control (Cont) group.