Fig. 1.
Effect of IL-2 treatment on circulating regulator T (TREG) cells in control and systemic lupus erythematosus (SLE) mice. A: representative gating strategy to identify CD4+Foxp3+ TREG cells. B: percentage of CD4+Foxp3+ TREG cells 48 h after three doses of IL-2. *P < 0.05 vs. the vehicle-treated control group; #P < 0.05 vs. all other groups. C: percentage of CD4+Foxp3+ T cells at the conclusion of the study. ^P < 0.05 vs. vehicle- and IL-2-treated control groups. D: percentages of CD3+CD4+ T lymphocytes at the conclusion of the study. ^P < 0.05 vs. vehicle- and IL-2-treated control groups. P values were generated using one-way ANOVA followed by a Tukey’s post test for multiple comparisons.