Fig. 4.

Scattered tubular-like cell (STC) mitochondrial morphology. A: STC mitochondrial area increased in the lean diet-fed (Lean) + renal artery stenosis (RAS) and metabolic syndrome (MetS) + RAS groups compared with the Lean and MetS groups. Mitochondrial matrix density, which decreased in the Lean + RAS and MetS + RAS groups versus their respective controls, further decreased in the MetS + RAS group. Elamipretide (ELAM) decreased mitochondrial area and increased matrix density of Lean + RAS and MetS + RAS STCs. B: the number of fusion events was similar among the groups. *P < 0.05 vs. the Lean group; †P < 0.05 vs. the MetS group; ‡P < 0.05 vs. the Lean + RAS group. ♠MetS: significant effect of MetS (two-way ANOVA); ♣Ischemia: significant effect of ischemia (two-way ANOVA).