Fig. 7.

Scattered tubular-like cells (STCs) reparative capacity. A: STC-protective effects were assessed by their capacity to improve viability of proximal tubular epithelial cells (PK1 cells) coincubated with 10 ng/ml TNF-α and 10 µM antimycin-A (AMA). Injured PK1 cells were untreated or treated with lean diet-fed (Lean) STCs or metabolic syndrome (MetS) + renal artery stenosis (RAS) STCs untreated or preincubated with elamipretide (ELAM; 1 nM for 6 h). B: TNF-α and AMA impaired the viability of swine PK1 cells, which was improved by Lean STCs but not by MetS + RAS STCs. ELAM improved the capacity of MetS + RAS STCs to increase the viability of PK1 cells. *P < 0.05 vs. PK1; †P < 0.05 vs. PK1 + TNF-α/AMA.