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. 2019 Nov 11;15:1744806919886503. doi: 10.1177/1744806919886503

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Prophylactic treatment with LEV and BRV prevents the development of mechanical allodynia and thermal hyperalgesia in the murine sciatic n. cuff model. After unilateral sciatic n. cuffing, mice were randomly assigned to receive vehicle (Veh) or LEV (100 or 10 mg/kg) or BRV (10 or 1 mg/kg) starting on the day of surgery and continuing daily until day 21; von Frey filaments were used to assess ipsilateral and contralateral hindpaw withdrawal thresholds; withdrawal thresholds (mean ± standard error) are plotted as a function of time for ipsilateral (filled symbols) and contralateral (empty symbols) hindpaws of mice receiving vehicle versus LEV (a), or vehicle versus BRV (b); five mice per group; **P < 0.01 with respect to vehicle treatment. (c) Thermal sensitivity was assessed on day 14 after sciatic n. cuffing using Hargreaves test in mice-administered vehicle versus BRV (10 mg/kg). CTR: control; PNI: peripheral n. injury; IPSI: ipsilateral; CONTRA: contralateral.