Value of the Data •The presented data provide further details on how the polygenic activity score to evaluate the efficiency of Tyr to OHTyr conversion was generated. •This report describes the effects on cardiovascular biomarkers of an intervention with white wine and white wine enriched with Tyr. •They are useful to predict the effects of nutritional interventions rich in Tyr (olive oil, wine, beer …) considering the interaction with individual's genetic background. •The present data are of interest for the effects of Tyr alone and in the future within Tyr rich foods •These data can be used for the design of new nutraceutical based on Tyr ingestion in humans