Table 1.
Demographic characteristics of clinically and neuropathologically characterized patients and controls by study centre
| Centre | Phenotype Groups |
|||
|---|---|---|---|---|
| NC/PDnD | DLB | PDD | Total N of individuals by centre (males, %) | |
| Newcastle Brain Tissue Resource (NBTR) | ||||
| N (Males, %) | -/31 (67.74) | 86 (59.30) | 38 (63.16) | 155 (60.75) |
| Mean age at onset of PD (SD) | -/64.69 (10.93)∗ | 74.51 (7.13)∗ | 64.92 (8.62) | |
| Mean age at onset of Dementia (SD) | - | 74.03 (8.02) | 71.68 (6.52) | |
| Mean age at death (SD) | -/77.52 (7.4) |
78.98 (7.21) |
76.13 (5.68) |
|
| NC/PDnD |
DLB-AD/DLB+AD |
PDD-AD/PDD+AD |
||
| Parkinson's UK Brain Bank at Imperial College London (PUK-ICL) | ||||
| N (Males, %) | -/42 (69.05) | 8 (87.50)/7 (71.43) | 43 (69.77)/12 (66.67) | 112 (70.54) |
| Mean age at onset of PD (SD) | -/66.50 (±10.43) | 72.38 (±5.34)/69.29 (±8.88) | 62.63 (±8.89)/64.08 (±8.51) | |
| Mean age at onset of Dementia (SD) | - | 72.75 (±5.12)/69.71 (±8.67) | 74.19 (±7.22)/76.08 (±4.98) | |
| Mean age at death (SD) | -/78.24 (±8.12) | 76.62 (±4.34)/79.47 (±7.01) | 77.42 (±6.99)/78.67 (±5.28) | |
| Oxford University Brain Bank (UO) | ||||
| N (Males, %) | 86 (51.16)/- | 29 (67.74)/33 (48.39) | - | 148 (54.05) |
| Mean age at onset of PD (SD) | - | - | - | |
| Mean age at onset of Dementia (SD) | - | 73.07 (±9.12)/72.11 (±7.65) | - | |
| Mean age at death (SD) | 81.81 (±10.90)/81.55 (±9.47) | 81.68 (±7.94)/80.68 (±6.17) | - | |
| Munich Brain Bank at Ludwig-Maximilians-University (LMU) | ||||
| N (males, %) | -/11 (54.55) | 10 (50)/6 (50) | 6 (50)/3 (66.67) | 36 (52.78) |
| Mean age at death (SD) | -/74.92 (±6.4) | 75.30 (±7.72)/75.17 (±8.42) | 73.67 (±3.27)/77.33 (±6.81) | |
| Total N of individuals by phenotype, (Males, %) | 170 (58.82) | 179 (59.78) | 102 (65.68) | 451 (62.57) |
NOTE. Each study contributed data available for each specific phenotype group. Some centres did not have specific phenotypes represented. The ICL centre data contained seven (males, 71.43%) PDnD-AD (Parkinson's disease without dementia with neuropathologically defined Alzheimer's disease), mean age of onset of PD (Parkinson's disease) 66.29 (±11.44) y, mean age at death 80.29 (±9.09) y, which were not used on any analyses presented in this report because of the low number of available subjects. The concomitant AD pathology data were not available for Newcastle cases.
Abbreviations: NC, normal controls; PDnD, Parkinson's disease without dementia; PDD-AD/PDD+AD, Parkinson's disease with dementia with/without neuropathologically defined Alzheimer's disease; DLB-AD/DLB+AD, dementia with Levy bodies with/without neuropathologically defined AD.
Some individuals did not have this information.