Table 3.
Effects of APOE-ε4 allele on the risk of dementias related to Parkinson's disease and dementia with Lewy bodies
| Case group, N individuals | Control group, N individuals | Frequency of effect allele (ε4) |
OR (95% CI) | P value | P value adjusted for TOMM40-L effect | |
|---|---|---|---|---|---|---|
| Case group, % | Reference group, % | |||||
| PDnD, 84 | NC, 86 | 14.9 | 11.1 | 1.26 (0.66–2.45) | .49 | .43 |
| PDD, 102 | NC and PDnD, 170 | 21.6 | 12.9 | 1.70 (1.07–2.70) | .02 | .40 |
| DLB, 179 | NC and PDnD, 170 | 34.6 | 12.9 | 3.75 (2.50–5.76) | 4.90 × 10−10 | .03 |
| DLB, 179 | PDD, 102 | 34.6 | 21.6 | 2.17 (1.44–3.36) | 3.44 × 10−4 | .22 |
| DLB+AD, 46 | NC and PDnD, 170 | 43.5 | 12.9 | 5.65 (3.06–10.43) | 2.97 × 10−8 | 8.29 × 10−4 |
| PDD+AD, 15 | NC and PDnD, 170 | 13.3 | 12.9 | 1.00 (0.29–2.72) | 1.00 | .24 |
| DLB-AD, 47 | NC and PDnD, 170 | 23.4 | 12.9 | 1.90 (1.09–3.29) | .023 | .13 |
| PDD-AD, 49 | NC and PDnD, 170 | 21.4 | 12.9 | 1.62 (0.92–2.80) | .09 | .20 |
NOTE. The results are reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Model tested: APOE-ε4 allele log-additive effect on risk compared to combined effect of other alleles, adjusted for age at death and sex. We also adjusted the same model for the additive effect of TOMM40-L allele.
Results in bold are statistically significant after correction for multiple testing (P value < .0021).
Abbreviations: NC, normal controls; PDnD, Parkinson's disease without dementia; PDD+AD/PDD-AD, Parkinson's disease with dementia with/without neuropathologically defined Alzheimer's disease; DLB+AD/DLB-AD, dementia with Levy bodies with/without neuropathologically defined AD.