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. 2019 Oct 18;6:1114–1126. doi: 10.1016/j.toxrep.2019.10.016

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Cytotoxicity of TAM, SIM and their combinations in T47D breast cancer cell line after 72 h. Surviving fraction of T47D treated with different concentrations of TAM (A). Surviving fractions of T47D treated with different concentrations of SIM (B). Combined cytotoxicity effect of 5 μM TAM and different concentrations of SIM (0.5–2.5 μM) in T47D cells (C). Isobologram analysis of combination of TAM and SIM in T47D cell line (D). Values are the means ± SD of three independent experiments performed in triplicates. a: significantly different from the control group and b: significantly different from TAM-treated group at P value < 0.05.