Figure 1.

LINC complex connects the external actin cytoskeleton to the nucleoskeleton. The nuclear envelope, nucleoskeleton, and their binding partners facilitate mechanical coupling between cytoplasmic and nuclear cytoskeletons. LINC complexes composed of Sun trimers and Giant Nesprin mechanically couple the actin cytoskeleton, and involve FHOD1 and Torsin facilitated LINC assembly. Chromatin interacts with nuclear structural elements to regulate gene expression including lamin B (through lamin B receptor, LBR), lamin A/C (via lamin-associated domains, LADs), and actin filaments. Inside the nucleus, G-actin is assembled into linear rods via mDia and into branched networks via the Arp2/3 complex, and interacts with lamin structure of the nucleoskeleton. (A color version of this figure is available in the online journal.)