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Microtubule network stabilization in heart failure. (a) Schematic of C-terminal detyrosination and luminal acetylation. (b to d) Microtubule detyrosination, desmin, and MAP4 are consistently increased in human heart failure (modified from Chen et al.23) (e and f) Immunofluorescence. Microtubules intersect with desmin intermediate filaments at the Z-disc of healthy and failing human cardiomyocytes. (A color version of this figure is available in the online journal.)
