Figure 2.

A network of LINC proteins and their functions at the nuclear envelope. A large, mostly conserved, network of C. elegans proteins regulates nuclear positioning and other functions throughout development. The purple layer contains SUN proteins and the proteins they interact with in the nuclear lamina. KASH proteins in the outer nuclear membrane are in the blue layer. The green layer contains the effectors that KASH proteins directly interact with. The yellow-green layer lists the cytoskeletal elements regulated by the KASH effectors. The cytoskeletal players then provide the mechanical forces to produce the cellular outputs listed in the top, orange layer. Unknown or hypothesized players are in gray. All black arrows are supported by genetic and/or biochemical evidence as described and referenced throughout the text. (A color version of this figure is available in the online journal.)