Table 1.
Examples of cell adhesion molecules, which bind directly or indirectly via linker proteins to spectrins.
| Cell adhesion molecule | Isoforms of spectrin | Interaction (references) |
|---|---|---|
| NCAM | βI-spectrin | Direct56,57 |
| αII-spectrin | Via 14.3.3β protein58 | |
| L1 | Spectrin | Via ankyrin B59,60 |
| αII-spectrin | Direct61 | |
| Neuroglian | Spectrin | Via ankyrin62,63 |
| CHL1 | βII-spectrin | Direct61 and via ankyrin64 |
| Neurofascin | Spectrin | Via ankyrin G59,65,66 |
| βII-spectrin | 67 | |
| NrCAM | Spectrin | Via ankyrin68 |
| SynCAM 1 | Spectrin | Via band 4.1-like protein 3, also called 4.1B69 |
| Lu/B-CAM | αI-spectrin | Direct70 |
| αII-spectrin | Direct71 | |
| ICAM | αII-spectrin | Not shown, via LFA-150 |
| Ig-CAM Roughest | βH-spectrin (Drosophila) | Direct72 Via annexin B973,74 |
CHL1: close homolog of L1; ICAM: intercellular adhesion molecule; LFA-1: lymphocytes function-associated antigen 1; NCAM: neural cell adhesion molecule.