TABLE 1.
Donor IDa | Donor HLA class I allele(s) | Sex/age at deathb (yr) | Age at onset (yr) | Disease duration (yr) | Therapyc | Cause of deathd | Postmortem delay (h) |
---|---|---|---|---|---|---|---|
MS79 | A*0201 | F/49 | 25 | 24 | Courses of ACTH, azathioprine, and methylprednisolone over 2 yr | MS | 7 |
MS92 | B*0801 | F/37 | 20 | 17 | None reported | MS | 26 |
MS121 | B*0801 | F/49 | 35 | 14 | Methylprednisolone for 1 yr | MS | 24 |
MS154 | B*0801 | F/35 | 23 | 12 | None reported | MS | 12 |
MS180 | B*0801 | F/44 | 26 | 18 | None reported | MS | 9 |
MS234 | B*0801 | F/39 | 24 | 15 | None reported | MS | 15 |
MS286 | A*0201 | M/46 | 30 | 16 | None reported | MS | 7 |
MS289 | A*0201, B*0702 | M/45 | 27 | 18 | None reported | MS | 9 |
MS330 | B*0702 | F/59 | 20 | 39 | None reported | MS | 21 |
MS342 | A*0201, B*0702 | F/35 | 30 | 5 | None reported | MS | 9 |
MS352 | B*0801 | M/43 | 25 | 18 | Methylprednisolone and alemtuzumab (one course each) 10 yr before death | MS | 26 |
MS356 | B*0702 | F/45 | 29 | 16 | None reported | MS | 10 |
All MS donors were in the progressive phase of the disease.
F, female; M, male.
ACTH, adrenocorticotropic hormone.
MS is stated as a cause of death where death occurred as a direct result of MS or any related disability.