TABLE 2.
HLA class I allele restriction of MS brain tissue donors and antigens and peptide epitopes analyzed by in situ pentamer staining
| MS donor HLA class I alleles suitable for in situ pentamer binding and MS donor ID | EBV protein/epitope coordinates | EBV epitope sequence | CMV protein/epitope coordinates | CMV epitope sequence | Influenza A protein/epitope coordinates | Influenza A epitope sequence | MBP epitope coordinates | MBP epitope sequence |
|---|---|---|---|---|---|---|---|---|
| A*0201 | ||||||||
| MS79, MS286, MS289, MS342 | EBNA3C/284–293 | LLDFVRFMGV | pp65/495–504 | NLVPMVATV | MP/58–66 | GILGFVFTL | 110–118 | SLSRFSWGA |
| LMP1/125–133 | YLLEMLWRL | |||||||
| LMP2/356–364 | FLYALALLL | |||||||
| LMP2/426–434 | CLGGLLTMV | |||||||
| BRLF1/109–117 | YVLDHLIVV | |||||||
| BMLF1/259–267 | GLCTLVAML | |||||||
| BALF4/276–284 | FLDKGTYTL | |||||||
| B*0702 | ||||||||
| MS289, MS330, MS356, MS342 | EBNA3A/247–255 | RPPIFIRRL | pp65/265–275 | RPHERNGFTVL | NP/473–481 | SPIVPSFDM | ||
| EBNA3C/881–889 | QPRAPIRPI | |||||||
| BMRF1/116–128 | RPQGGSRPEFVKL | |||||||
| B*0801 | ||||||||
| MS92, MS121, MS154, MS180, MS234, MS352 | EBNA3A/193–201 | FLRGRAYGL | IE1/88–96 | QIKVRVDMV | ||||
| BZLF1/190–197 | RAKFKQLL |