TABLE 1.

Differentially expressed immunity-related genes

No.	Gene symbol	Accession no.	Description	Function	Change factor (in F48E9 relative to that in LaSota)
1	B2M	NM_001001750	β-2-Microglobulin	Immune response	11.72
2	BF2	NM_001031338	Major histocompatibility complex class I antigen BF2	Immune response	24.52
3	CARD11	NM_001006161	Caspase recruitment domain family, member 11	Positive regulation of NF-κB transcription factor activity	6.12
4	HSPD1	NM_001012916	Heat shock 60 kDa protein 1 (chaperonin)	MyD88-dependent Toll-like receptor signaling pathway; positive regulation of IFN-α production; positive regulation of macrophage activation	−2.03
5	IL18	NM_204608	Interleukin 18 (IFN-γa-inducing factor)	Positive regulation of IFN-γ production; IFN-γ biosynthetic process; positive regulation of natural killer cell proliferation	38.63
6	IRF1	NM_205415	Interferon regulatory factor 1	Induction of IFN; antivirus; anti-tumor	27.46
7	IRF7	NM_205372	Interferon regulatory factor 7	Toll-like receptor signaling pathway; activation of innate immune response	10.63
8	IRF8	NM_205416	Interferon regulatory factor 8	Immune response; positive regulation of IFN-γ production	4.73
9	JMJD6	NM_001030703	Jumonji domain containing 6	Macrophage activation	−3.15
10	MYD88	NM_001030962	Myeloid differentiation primary response gene (88)	MyD88-dependent Toll-like receptor signaling pathway	2.91
11	TLR15	NM_001037835	Toll-like receptor 15	Critical component of the innate immune response	59.64
12	TMEM173	XM_001232170	Transmembrane protein 173	Innate immune response; defense response to virus; IFN-β production	18.03
13	TNFRSF8	NM_204444	Tumor necrosis factor receptor superfamily, member 8	Cytokine-mediated signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; tumor necrosis factor-mediated signaling pathway	17.47
14	UBA52	NM_205075	Ubiquitin A-52 residue ribosomal protein fusion product 1	Toll-like receptor signaling pathway; MyD88-dependent Toll-like receptor signaling pathway; activation of MAPK activity involved in innate immune response	−2.02

^aIFN-γ, gamma interferon.