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(A) SF3b1 interactions with the BPS – U2 snRNA duplex. The PHF5a subunit is omitted for clarity and would overlay the branch point adenosine (BP-A, magenta surface) facing the viewer. Sites of pladienolide-resistant mutations are green. (B) SF3b1 interactions with the pre-mRNA intron. PDB ID 5Z58. Mutational hotspots are colored yellow. For reference between panels, the pre-mRNA nucleotides are numbered relative to the BP-A. HR, HEAT repeat.
