Skip to main content
. Author manuscript; available in PMC: 2019 Nov 27.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2019 Nov 9;1862(11-12):194440. doi: 10.1016/j.bbagrm.2019.194440

Figure 8.

Figure 8.

(A) Comparison of the SF3b1 conformation in the SF3b particle (gray, PDB ID 5IFE) compared to SF3b bound to inhibitors pladienolide B (PB) (cyan, PDB ID 6EN4) or E7107 (magenta, PDB ID 5ZYA). PB is shown as yellow spheres for reference. (B) Close view of SF3b1 interactions with PB (yellow surface) (PDB ID 6EN4). SF3b1 residues for which mutations confer pladienolide-resistance are green. PHF5a is shown in gray. The interactions of SF3b1 with E7107 (PDB ID 5ZYA) are nearly identical with the exception of an additional cycloheptyl-piperazine moiety.