Table 2.

MR estimates of the causal effect of amyloid on t-tau and p-tau as well as the causal effect of t-tau on amyloid

Study type	Methods	β	se	95% CI	P value
Amyloid SNPs with t-tau	MR Egger	0.85	0.15	0.54 to 1.15	<.001
	Weighted median	0.73	0.22	0.31 to 1.16	<.001
	IVW	0.86	0.11	0.65 to 1.08	<.001
	Simple median	0.81	0.50	−0.17 to 1.80	.110
Amyloid SNPs with p-tau	MR Egger	0.73	0.17	0.39 to 1.06	<.001
	Weighted median	0.62	0.23	0.17 to 1.06	.006
	IVW	0.86	0.12	0.62 to 1.10	<.001
	Simple median	1.31	0.52	0.29 to 2.33	.014
t-tau SNPs with amyloid	MR Egger	−0.45	0.36	−1.15 to 0.26	.23
	Weighted median	−0.31	0.29	−0.87 to 0.25	.27
	IVW	−0.02	0.20	−0.42 to 0.38	.93
	Simple median	−0.20	2.05	−4.22 to 3.81	.92

Abbreviations: β, β coefficient; CI, confidence interval; IVW, inverse-variance weighted; MR, Mendelian randomization; t-tau, total tau; p-tau, phosphorylated tau; SNP, single nucleotide polymorphism.