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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Biomed Mater Res A. 2019 Sep 5;108(1):39–49. doi: 10.1002/jbm.a.36790

FIGURE 9.

FIGURE 9

In vivo characterization of the efficacy and tolerance of bacteriophage-encapsulating hydrogels in a murine radial segmental defect model. (a) Log transform of live PsAer-9 recovered from in an infected radial defect model treated standard and bacteriophage-encapsulating hydrogels. (b) Log transform of live bacteriophage recovered from in an infected radial defect model treated with standard and bacteriophage-encapsulating hydrogels. 3 μl gels containing 1 mM GFOGER, 30 ng BMP-2,1.2e8 PFU/ml each of ΦPaer4, ΦPaer14, ΦPaer22, and ΦW2005A, and 3.0 × 104 CFU PsAer-9, crosslinked with VPM. Two-tailed t test. Mean ± SEM, n = 5 per group, **p < 0.01, ***p < 0.001