Fig. 4.

Unsupervised clustering results are shown as a two-dimensional dendrogram for 21 chemicals that were identified as exhibiting aneugenic activity. As described in Materials and Methods section, each biomarker dose response was converted to an area under the curve for this analysis. The abbreviations TB (tubulin binder) and KI (kinase inhibitor) are used to denote clades with chemicals that are known to exhibit these activities. The bottommost graph shows the horizontal distances between join points.